The Effect of Mamordica charalltia L. Powder on The Status of Antioxidant Superoxide Dismutase in Liver and Kidney of Diabetic Rats

Abstract

The status ojcnlioxidal;f superoxide dismurase (SOD) \las repfJrted decrecsed m the Jj,'er tissues f.;/diaberlcexperimenral Macaea fascicularis. The aim oflhe study was to observe the effect of pare (Mam:>rdica charantia) olllhe status o/SOD in the liver and kidney of diabetic experimental rats. The SOD was localized using immunohistochemical technique. A lotal 0/20 male Wistar rats were usedJor this study. They were divided into Jour groups: (I) negative control group, (2) positi~'e control group (diabetes mellitus groupIDM); (3) and (4) groups were DM groups that treared wilh 5 and 10% pare powder. The DM condition was achieved by alloxan (J 10 mglKgBB) induction. Treatment a/pare was done/or 28 days. The results showed that pare increased the status oj antioxidant SOD in the liver and kidney oj diabetic experimental rats. The 10% pare powder gave better results than that 015%. Tlfe results suggested thai pare powdu can be used to increase the status 0/ antioxidant ;n fhe OXidative stress condition, such as diabetes mellitus. Keywords: superoxide dismutase, Jlamordica charanlta, diabetes mellitus, liver, kidney, immunohistochemistry