A Comprehensive Study of Clinical, Hematological, Biochemical, and Serological Profiles in Cats Infected with Feline Coronavirus (FCoV).

Abstract

Feline Coronavirus (FCoV) is prevalent among domestic cats, particularly in multi-cat and outdoor-access environments, and can mutate into the fatal disease Feline Infectious Peritonitis (FIP). This study examined 45 FCoV-positive cats from a clinic in Selangor, Malaysia, using clinical evaluation, hematology, biochemistry, and Immunoassay titer testing. Infections were most common in cats aged 1 – 6 years. High antibody titers (= S5) linked with neurological, systemic, and gastrointestinal signs typical of FIP. Hematological findings included neutrophilia (60.71%), monocytosis (60.71%), and anemia (32.14%). Biochemical abnormalities include hyperbilirubinemia (100%), hypoalbuminemia (85.71%), hyperglobulinemia (89.29%), and low A/G ratios (100%) were consistent with FIP pathology. These results support the diagnostic value of combining clinical and laboratory data, while underscoring the need for improved FIP surveillance and early detection.