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http://repository.ipb.ac.id/handle/123456789/156855
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DC Field | Value | Language |
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dc.contributor.advisor | Purwono, Rini Madyastuti | - |
dc.contributor.advisor | Dewi, Fitriya Nur Annisa | - |
dc.contributor.author | Putri, Shafwa Adinda Chairi | - |
dc.date.accessioned | 2024-08-09T06:45:19Z | - |
dc.date.available | 2024-08-09T06:45:19Z | - |
dc.date.issued | 2024 | - |
dc.identifier.uri | http://repository.ipb.ac.id/handle/123456789/156855 | - |
dc.description.abstract | Nefrolithiasis atau pembentukan batu ginjal dapat disebabkan oleh peningkatan kadar oksalat dalam tubuh. Kombinasi herbal alpukat dan alang-alang dikembangkan sebagai bahan yang berpotensi sebagai antilithiasis. Penelitian ini bertujuan mengkaji efek kombinasi herbal daun alpukat dan akar alang-alang terhadap jumlah leukosit dan diferensial leukosit pada model tikus galur Sprague- Dawley yang diinduksi etilen glikol dan ammonium klorida sebagai hewan model hiperoksaluria. Tikus dibagi menjadi 5 kelompok perlakuan yaitu kontrol normal, kontrol negatif, kontrol positif, kombinasi ekstrak akar alang-alang dosis 100 mg/kg BB dan ekstrak daun alpukat dosis 300 mg/kg BB, serta kombinasi ekstrak akar alang-alang dosis 300 mg/kg BB dan ekstrak daun alpukat dosis 100 mg/kg BB. Perlakuan diberikan selama 28 hari, dan sampel darah dikoleksi pada hari ke-14 dan 28. Kadar limfosit dan monosit tidak menunjukkan perbedaan nyata antar kelompok perlakuan. Terdapat perbedaan nyata pada rataan jumlah leukosit antara kelompok kombinasi dengan kontrol negatif pada hari ke-28. Kelompok ALP-al menunjukkan rataan granulosit yang lebih rendah dibandingkan dengan kontrol negatif (p<0,05). Kedua kombinasi ekstrak menunjukkan potensi dalam menurunkan peradangan pada hari ke-28 pasca induksi hiperoksaluria, dan kombinasi herbal yang didominasi daun alpukat memiliki potensi efek antiinflamasi yang lebih baik. | - |
dc.description.sponsorship | Nephrolithiasis or kidney stone formation can be caused by increased oxalate levels in the body. This study aims to evaluate the effects from combinations of herbs with potential antilithiasis properties such as avocado leaves and cogon grass roots on the total absolute of leukocytes and differential leukocyte data on the 14th and 28th days from white rats that were induced with ethylene glycol and ammonium chloride. Male Sprague-Dawley white rats were divided into 5 treatment groups, namely normal control, negative control, positive control, the 100 mg/kg BW cogon grass roots extract and 300 mg/kg BB avocado leaves extract combination, as well as the 300 mg/kg BW cogon grass roots extract and 1100 mg/kg BB avocado leaves extract combination. Lymphocyte and monocyte levels did not show any significant differences (p>0,05) between treatment groups. The results of the study showed that there was a difference in the average number of leukocytes between the combination groups and the negative control. In addition, ALP-al group also showed decreased granulocyte counts compared to negative controls (p<0,05). Both combinations of extracts showed good antilithiasis effect, though the avocado leaves-dominant combination showed a better anti- inflammatory effect. | - |
dc.language.iso | id | - |
dc.publisher | IPB University | id |
dc.title | Profil Leukosit Tikus Sprague-Dawley Model Hiperoksaluria yang Diberi Kombinasi Ekstrak Daun Alpukat dan Akar Alang-alang | id |
dc.title.alternative | Leucocyte Profiles on Sprague-Dawley Rats Model of Hyperoxaluria That was Given Avocado Leaves and Cogon Grass Roots Combined Extracts | - |
dc.type | Skripsi | - |
dc.subject.keyword | nefrolithiasis | id |
dc.subject.keyword | daun alpukat | id |
dc.subject.keyword | akar alang-alang | id |
dc.subject.keyword | leukosit | id |
dc.subject.keyword | diferensial leukosit | id |
Appears in Collections: | UT - Anatomy, Phisiology and Pharmacology |
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cover_B0401201034_ec0526e05cb349098c6061fc64d64fa8.pdf | Cover | 903.5 kB | Adobe PDF | View/Open |
fulltext_B0401201034_a44151ad2f2041f2927b2475a948f53e.pdf Restricted Access | Fulltext | 1.07 MB | Adobe PDF | View/Open |
lampiran_B0401201034_98d8c74f6f02418a9a275ecdf95dabd4.pdf Restricted Access | Lampiran | 514.86 kB | Adobe PDF | View/Open |
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