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http://repository.ipb.ac.id/handle/123456789/154288
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DC Field | Value | Language |
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dc.contributor.advisor | Mustika, Aulia Andi | |
dc.contributor.advisor | Satyaningtijas, Aryani Sismin | |
dc.contributor.author | Ardiana, Alvina Gitacahyani | |
dc.date.accessioned | 2024-07-19T04:08:31Z | |
dc.date.available | 2024-07-19T04:08:31Z | |
dc.date.issued | 2024 | |
dc.identifier.uri | http://repository.ipb.ac.id/handle/123456789/154288 | |
dc.description.abstract | Getah gambir sudah banyak dimanfaatkan oleh masyarakat untuk mengatasi berbagai penyakit, salah satunya adalah diare. Penelitian ini bertujuan untuk mengetahui efektivitas getah gambir sebagai antidiare dengan menggunakan metode proteksi intestinal yang dilihat dari parameter frekuensi, konsistensi, dan durasi. Penelitian ini juga bertujuan menentukan konsentrasi yang paling efektif dalam memberikan efek antidiare pada mencit dan mengetahui metabolit sekunder yang terkandung dalam getah gambir dengan uji fitokimia. Hewan coba dalam penelitian ini menggunakan mencit sebanyak 30 ekor dengan dibagi menjadi 5 kelompok. Kelompok perlakuan terdiri atas kelompok kontrol negatif, kontrol positif, dan tiga kelompok perlakuan yang diberi infusa getah gambir dengan konsentrasi 25%, 50%, dan 100% secara oral. Parameter yang dinilai dalam metode proteksi intestinal adalah frekuensi defekasi, konsistensi feses, dan durasi diare. Hasil penelitian menunjukkan getah gambir memiliki metabolit sekunder yang berpotensi sebagai antidiare seperti alkaloid, flavonoid, saponin, dan tanin pada uji fitokimia. Hasil dari metode proteksi intestinal menunjukkan kelompok perlakuan infusa getah gambir konsentrasi 25%, 50%, dan 100% terbukti mampu menurunkan frekuensi defekasi, memperbaiki konsistensi, dan mempersingkat waktu diare. Kelompok konsentrasi 25% dan 50% menunjukkan aktivitas antidiare lebih baik daripada konsentrasi 100%. | |
dc.description.abstract | Gambier extract has been widely used by the community to treat various diseases, one of which is diarrhea. This study aims to determine the effectiveness of gambier sap as an antidiarrhea using intestinal protection methods as seen from the parameters of frequency, consistency and duration. This research also aims to determine the most effective concentration in providing antidiarrheal effects in mice and determine the secondary metabolites contained in gambier sap using phytochemical tests. The experimental animals in this study used 30 mice divided into 5 groups. The treatment groups consisted of a negative control group, a positive control, and three treatment groups that were given gambier extract infusion at concentrations of 25%, 50%, and 100% orally. The parameters assessed in the intestinal protection method are defecation frequency, fecal consistency, and duration of diarrhea. The research results showed that gambier extract has secondary metabolites that have the potential to act as antidiarrhea such as alkaloids, flavonoids, saponins and tannins in phytochemical tests. The results of the intestinal protection method showed that the gambier extract infusion treatment group with concentrations of 25%, 50%, and 100% was proven to be able to reduce the frequency of defecation, improve consistency, and shorten the time of diarrhea. The 25% and 50% concentration groups exhibited better antidiarrheal activity than the 100% concentration | |
dc.description.sponsorship | Dana hibah dari dosen ke mahasiswa | |
dc.language.iso | id | |
dc.publisher | IPB University | id |
dc.title | Efektivitas Infusa Getah Gambir (Uncaria gambir Roxb) Sebagai Antidiare pada Mencit (Mus musculus) | id |
dc.title.alternative | Effectiveness of Gambier Extract Infusion (Uncaria gambir Roxb) as Antidiarrhea in Mice (Mus musculus) | |
dc.type | Skripsi | |
dc.subject.keyword | antidiare | id |
dc.subject.keyword | infusa | id |
dc.subject.keyword | proteksi intestinal | id |
dc.subject.keyword | uji fitokimia | id |
dc.subject.keyword | Getah gambir | id |
Appears in Collections: | UT - Anatomy, Phisiology and Pharmacology |
Files in This Item:
File | Description | Size | Format | |
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cover_B0401201109_7356adb07f03487c825bdc6822e00ba6.pdf | Cover | 1.26 MB | Adobe PDF | View/Open |
fulltext_B0401201109_2b44b6eb4e10438cb5e804e34eba6bc8.pdf Restricted Access | Fulltext | 1.51 MB | Adobe PDF | View/Open |
lampiran_B0401201109_2d7e948377dc47318fdb9168b1ec5cc5.pdf Restricted Access | Lampiran | 409.59 kB | Adobe PDF | View/Open |
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