The Effectiveness of Cayenne Pepper (Capsicum annuum) on Analgesic Effect and Stamina in Male Mice (Mus musculus)

Abstract

Cayenne is used all over the world and is mostly used in cooking as a spice that is added to different dishes and sauces to give them flavour, colour, and perfume. Chilli peppers are a member of the genus Capsicum and has a compound found in chilli peppers that is active is called capsaicin (8-methyl-N-vanillyl-6 nonenamide). The term "fatigue" is frequently used and has multiple definitions, causal relationships, and domains. Capsaicin is a useful tool in the study of pain since it causes pain in addition to the feeling of heat. Mice's stamina can be increased by flavonoids through their inhibition of the phosphodiasterase enzyme, which is responsible for converting cAMP to AMP. This study determined the effectiveness of cayenne pepper (Capsicum annuum) on analgesic effect and stamina. The tail flick test was used to determine the analgesic effect of the treatment on mice. The swimming endurance test was used to determine the stamina of the mice. A total of 20 mice were used and divided into 4 treatment groups: control, 1, 2 and 4 mg/g BW. To determine the statistical significance of the data, ANOVA one-way and Tukey tests were conducted. Based on the statistical analysis, cayenne pepper was effective to increase stamina at 4 mg/g BW whereas cayenne pepper was effective to increase analgesic effect at 2 and 4 mg/g BW. In conclusion, cayenne pepper shows effects on both stamina and analgesic effect.