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http://repository.ipb.ac.id/handle/123456789/132452
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DC Field | Value | Language |
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dc.contributor.advisor | Sulistiyani, Sulistiyani | - |
dc.contributor.advisor | Setyawati, Inda | - |
dc.contributor.author | Nurinayah, Irna | - |
dc.date.accessioned | 2023-11-17T06:06:35Z | - |
dc.date.available | 2023-11-17T06:06:35Z | - |
dc.date.issued | 2023 | - |
dc.identifier.uri | http://repository.ipb.ac.id/handle/123456789/132452 | - |
dc.description.abstract | Stres oksidatif di dalam tubuh dapat diatasi dengan menginhibisi protein Keap1 yang berasosiasi dengan Nrf2 dalam mekanisme persinyalan antioksidan. Penelitian bertujuan mengidentifikasi senyawa aktif ekstrak larva BSF yang dibudidayakan dengan substrat limbah dapur di Desa Sindangjaya, Cianjur sebagai antioksidan melalui pengujian DPPH dan prediksi in silico. Ekstraksi dilakukan menggunakan metode maserasi bertingkat dengan pelarut aseton dan metanol serta dengan maserasi pemanasan menggunakan pelarut air, kemudian dianalisis dengan LC-MS/MS dan diuji DPPH. Potensinya sebagai inhibitor Keap1 secara in silico dengan uji bioavailabilitas, ADME, toksisitas, dan penapisan virtual. Senyawa aktif 1,5-Bis(1H-benzotriazol-1-yl)-1,5-pentanedione di dalam ekstrak air dari golongan benzotriazoles memiliki nilai energi afinitas yaitu -7,01 kkal/mol dan Methyl (S)-2-((S)-2-((tert-butoxycarbonyl) amino)-3 cyclohexylpropanamido)-3-((S)-2-oxopyrrolidin-3-yl) propanoate di dalam ekstrak aseton dari golongan asam amino, peptida, dan turunanya memiliki nilai energi afinitas sebesar -6,49 kkal/mol. Kedua senyawa tersebut merupakan kandidat terbaik sebagai inhibitor Keap1 dalam persinyalan antioksidan karena berinteraksi dengan residu Cys151. | id |
dc.description.abstract | Oxidative stress in the body can be reduced by inhibiting the protein Keap1 from associating with Nrf2 in an antioxidant signaling mechanism. The study aimed to identify active compounds of BSF larvae extract cultivated with kitchen waste substrate in Sindangjaya Village, Cianjur as antioxidants with DPPH method and in silico prediction. Extraction was carried out using a multilevel maceration method with acetone and methanol solvents and followed by heated maceration with aqueous solvent. The extracts were analysed using LC-MS/MS method and DPPH test. Its potential as Keap1 inhibitor was predicted using in silico bioavailability test, ADME, toxicity, and virtual screening. The active compound of 1,5-Bis(1H-benzotriazol-1-yl)-1,5-pentanedione of the aqueous extract which is benzotriazoles group has an affinity energy value of -7,01 kcal/mol and Methyl (S)-2-((S)-2-((tert-butoxycarbonyl) amino)-3 cyclohexylpropanamido)-3-((S)-2-oxopyrrolidin-3-yl) propanoate in the acetone extract from the amino acid, peptides, and derivatives group has an affinity energy value of -6,49 kcal/mol. Both compounds are the best candidates for Keap1 inhibitors in antioxidant signaling due to their interaction with the Cys151 residue. | id |
dc.language.iso | id | id |
dc.title | Aktivitas Antioksidan In Vitro dan Regulasi Persinyalan Antioksidan In Silico oleh Ekstrak Larva Black Soldier Fly (Hermetia illucens) | id |
dc.title.alternative | In Vitro Antioxidant Activity and In Silico Antioxidant Signaling Regulation by Black Soldier Fly (Hermetia illucens) Larvae Extract | id |
dc.type | Undergraduate Thesis | id |
dc.subject.keyword | antioksidan | id |
dc.subject.keyword | DPPH | id |
dc.subject.keyword | in silico | id |
dc.subject.keyword | larva BSF | id |
dc.subject.keyword | protein Keap1 | id |
Appears in Collections: | UT - Biochemistry |
Files in This Item:
File | Description | Size | Format | |
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01 Watermark (Cover) - SKRIPSI - (G84190020) IRNA NURINAYAH.pdf Restricted Access | Cover | 362.8 kB | Adobe PDF | View/Open |
02 Watermark (Fullteks) - SKRIPSI - (G84190020) IRNA NURINAYAH.pdf Restricted Access | Full teks | 1.57 MB | Adobe PDF | View/Open |
03 Watermark (Lampiran) - SKRIPSI - (G84190020) IRNA NURINAYAH.pdf Restricted Access | Lampiran | 651.12 kB | Adobe PDF | View/Open |
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