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Title: | Efikasi Infusa Gum Arab sebagai Antidiare pada Mencit (Mus musculus) |
Other Titles: | Efficacy of Gum Arabic Infusion as an Antidiarrheal in Mice (Mus musculus) |
Authors: | Mustika, Aulia Andi Hadi, Upik Kesumawati Ginting, Febrina Malemita |
Issue Date: | Jul-2023 |
Publisher: | IPB University |
Abstract: | Gum arab digunakan oleh masyarakat Indonesia untuk mengobati beberapa penyakit. Beberapa senyawa aktif antidiare seperti saponin, tanin, dan flavonoid terkandung dalam gum arab. Penelitian ini bertujuan untuk mengetahui efikasi antidiare infusa gum arab menggunakan metode proteksi intestinal dan transit intestinal serta menentukan konsentrasi yang paling efektif pada mencit. Penelitian
ini menggunakan tiga puluh ekor mencit jantan yang dibagi menjadi enam kelompok yang terdiri dari kelompok kontrol negatif (tween 80 [1%]), kontrol positif (loperamide HCI), dan empat kelompok perlakuan infusa gum arab dengan konsentrasi bertingkat (12,5 %, 25%, 50%, dan 100%). Hasil metode proteksi intestinal menunjukkan bahwa semua kelompok konsentrasi infusa gum arab memiliki efek antidiare. Hasil metode transit intestinal menunjukkan hanya 12,5%
kelompok konsentrasi yang memiliki aktivitas antidiare, sehingga disimpulkan konsentrasi 12,5% memiliki efek antidiare terbaik Gum arabic is used by Indonesians to treat several diseases. Several active antidiarrheal compounds such as saponins, tannins, and flavonoids are present in gum arabic. This study aimed to determine the antidiarrheal efficacy of gum arabic infusion using intestinal protection and intestinal transit methods and determine the most effective concentrations in mice. This study used thirty male mice, which were divided into six groups consisting of a negative control (tween 80 [1%]), a positive control (loperamide HCI), and four treatment groups of gum arabic infusion with graded concentrations (12,5%, 25%, 50%, 100%). The intestinal protection methods result showed that all gum arabic infusion concentration groups had antidiarrheal effects. The intestinal transit methods showed that only 12,5% concentration group had antidiarrheal activity, it was concluded that concentration of 12,5% had the best antidiarrheal effect. |
URI: | http://repository.ipb.ac.id/handle/123456789/122196 |
Appears in Collections: | UT - Anatomy, Phisiology and Pharmacology |
Files in This Item:
File | Description | Size | Format | |
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Cover Febrina Malemita Br.Ginting_B04190034.pdf Restricted Access | Cover | 1.43 MB | Adobe PDF | View/Open |
B04190034-Febrina Malemita Br. Ginting.pdf Restricted Access | Fullteks | 1.88 MB | Adobe PDF | View/Open |
Lampiran Febrina Malemita Br.Ginting_B04190034.pdf Restricted Access | Lampiran | 410.7 kB | Adobe PDF | View/Open |
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