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http://repository.ipb.ac.id/handle/123456789/113151
Title: | Efektivitas Infusa Daun Keji Beling (Strobilanthes crispus Blume) sebagai Antidiare pada Mencit (Mus musculus) |
Other Titles: | The Effectiveness of Keji Beling (Strobilanthes crispus Blume) Leaf Infusion as Antidiarrheal in Mice (Mus musculus) |
Authors: | Mustika, Aulia Andi Sa'diah, Siti Zakiyah, Aida |
Issue Date: | 2022 |
Publisher: | IPB University |
Abstract: | Tanaman keji beling telah lama digunakan untuk pengobatan penyakit pada
manusia, namun penelitian terkait manfaat tanaman keji beling sebagai antidiare
masih sedikit. Tujuan penelitian ini adalah mengevaluasi secara ilmiah efek infusa
daun keji beling sebagai antidiare dengan metode proteksi intestinal dan transit
intestinal pada mencit. Penelitian ini menggunakan 36 ekor mencit yang dibagi
menjadi enam kelompok terdiri dari kelompok kontrol negatif (Tween 80 [1%]),
kontrol positif (suspensi loperamid HCl), dan empat kelompok perlakuan infusa
daun keji beling dengan konsentrasi 12,5%, 25%, 50%, dan 100% yang diberikan
secara oral. Parameter yang diamati yaitu frekuensi defekasi, konsistensi feses, dan
rasio lintasan marker usus. Berdasarkan metode proteksi intestinal, infusa daun keji
beling dengan konsentrasi 12,5%, 25%, dan 50% memiliki efek antidiare,
sedangkan pada metode transit intestinal hanya infusa daun keji beling konsentrasi
50% yang memiliki efek antidiare. Berdasarkan kedua metode, infusa daun keji
beling konsentrasi 50% menunjukkan efek antidiare yang paling efektif. Keji beling plant has long been used for the treatment of diseases in human, but research regarding the benefits of the keji beling plant as an antidiarrheal are still few. The purpose of this study was to evaluate scientifically the effect of keji beling leaf infusion as an antidiarrheal with intestinal protection and intestinal transit method in mice. This study used 36 mice which were divided into six groups consisting of a negative control group (Tween 80 [1%]), a positive control group (loperamide HCl suspension), and four groups of treatment with a keji beling leaf infusion concentration of 12,5%, 25%, 50%, and 100% given orally. The parameters observed were the frequency of defecation, the consistency of faeces, and the ratio of marker passages in the intestines of mice. Based on intestinal protection method, infusion of keji beling leaf with concentrations of 12.5%, 25%, and 50% has an antidiarrheal effect, while in the intestinal transit method only the infusion of keji beling leaf with concentration of 50% has an antidiarrheal effect. Based on the two methods, infusion of keji beling leaf at a concentration of 50% showed the most effective antidiarrheal effect. |
URI: | http://repository.ipb.ac.id/handle/123456789/113151 |
Appears in Collections: | UT - Anatomy, Phisiology and Pharmacology |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
COVER.pdf Restricted Access | Cover | 377.96 kB | Adobe PDF | View/Open |
FULL TEXT.pdf Restricted Access | Full Text | 542.2 kB | Adobe PDF | View/Open |
LAMPIRAN.pdf Restricted Access | Lampiran | 520.4 kB | Adobe PDF | View/Open |
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