Malignant Peripheral Nerve Sheath Tumor with Giant Cells development in a female African Pigmy Hedgehog (Atelerix albiventris)

Abstract

A subcutaneous mass was determined at the left abdominal area of African pygmy hedgehog. The case was very few in veterinary clinic since it found in the exotic animal. This valuable finding was then evaluated more detail especially for the morphological aspect. This study was aims to identified the tissue structure and it specific cell to get the best diagnosis the mass. A regular staining method and immunostaining using S100 antibody and PCNA antibody were applied in paraffin tissues sections. The mass has oval in form and covered by a thin transparent connective tissue and imagining glowing nodule. Evaluation on cross section surface showing spot black and white color tissue also a necrose image. The white tissue indicates a solid image and harder in consistent. The Hematoxylin-Eosin staining showed a dense of pleomorphic, spindle-shaped, and some multinucleated giant cells development. The immunostaining result express some cells are slightly positive to S100 (pale brown), while reactivity to PCNA is found strongly positive and it scatter in this tissue mass. Based on the evaluation of the used staining method could be conclude that the mass is Malignant Peripheral Nerve Sheath Tumor/MPNST with multiple foci of giant cells.