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http://repository.ipb.ac.id/handle/123456789/112228
Title: | Aktivitas Enzim Transaminase dan Kadar Urea Serum Darah Tikus yang Diinduksi 7,12-Dimetilbenz(α)antrasena dengan Perlakuan Kombinasi Ekstrak Temulawak dan Propolis |
Authors: | Suryani Hasan, Akhmad Endang Zainal Setiyono, Agus Salim, Afifah |
Issue Date: | 2022 |
Publisher: | IPB University |
Abstract: | Temulawak dan propolis diketahui memiliki senyawa aktif yang bermanfaat sebagai antikanker. Penelitian ini bertujuan menganalisis pengaruh kombinasi ekstrak temulawak dan propolis terhadap organ ginjal dan hati dalam proses pengobatan kanker payudara pada tikus Sprague-Dawley betina yang diinduksi DMBA. Parameter uji yang diamati ialah aktivitas enzim transaminase dan kadar urea. Sebanyak 37 ekor tikus dibagi secara acak menjadi tujuh kelompok, yakni kelompok EO, Normal, dan lima kelompok perlakuan yang diinduksi kombinasi ekstrak etanol temulawak dan propolis secara peroral dengan dosis berbeda. Pemberian kombinasi ekstrak etanol temulawak dan propolis terhadap aktivitas enzim transaminase pada dosis temulawak 52,5 mg/kg BB + propolis 72 mg/kg BB dan dosis temulawak 70 mg/kg BB + propolis 96 mg/kg BB memiliki potensi hepatoprotektif berdasarkan nilai rasio De Ritis yang mendekati 0,8. Hasil analisis kadar urea pada dosis temulawak 70 mg/kg BB + propolis 96 mg/kg BB memiliki nilai 32,235 mg/dL. Kombinasi ekstrak pada dosis temulawak 52,5 mg/kg
BB + propolis 72 mg/kg BB dan dosis temulawak 70 mg/kg BB + propolis 96 mg/kg BB memiliki potensi sebagai hepatoprotektif serta pemberian kombinasi ekstrak temulawak dan propolis tidak memengaruhi kadar urea darah pada semua kelompok dosis. Curcuma and propolis are known to have active compounds that have anticancer benefits. This study aimed to analyze the effect of the combination of curcuma extract and propolis on the kidneys and liver in the treatment of breast cancer in female Sprague-Dawley rats induced by DMBA. The test parameters observed were transaminases enzyme activity and urea levels. A total of 37 rats were randomly divided into sevent groups, namely the EO group, Normal, and five treatment groups which were induced by a combination of ethanol extract of curcuma and propolis orally with different doses. The administration of a combination of ethanol extract of curcuma and propolis on transaminase enzyme activity at a dose of curcuma 52.5 mg/kg BW + propolis 72 mg/kg BW and a curcuma dose of 70 mg/kg BW + propolis 96 mg/kg BW had hepatoprotective potential based on the De Ritis ratio value which is close to 0.8. The results of the analysis of urea levels at a dose of curcuma 70 mg/kg BW + propolis 96 mg/kg BW had a value of 32.235 mg/dL. The combination of extracts at a dose of 52.5 mg/kg BW of curcuma + propolis 72 mg/kg BW and a dose of curcuma 70 mg/kg BW + propolis 96 mg/kg BW has potential as hepatoprotective and the combination of curcuma and propolis extract did not affect blood urea level in all dose groups. |
URI: | http://repository.ipb.ac.id/handle/123456789/112228 |
Appears in Collections: | UT - Biochemistry |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Cover, Lembar Pengesahan, Prakata, Daftar Isi.pdf Restricted Access | Cover | 822.64 kB | Adobe PDF | View/Open |
G84160071_Afifah Salim.pdf Restricted Access | Fullteks | 1.08 MB | Adobe PDF | View/Open |
Lampiran.pdf Restricted Access | Lampiran | 778.74 kB | Adobe PDF | View/Open |
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