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http://repository.ipb.ac.id/handle/123456789/112081
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DC Field | Value | Language |
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dc.contributor.advisor | Falah, Syamsul | - |
dc.contributor.advisor | Ambarsari, Laksmi | - |
dc.contributor.author | Werdiningsih, Pertiwi | - |
dc.date.accessioned | 2022-06-17T00:09:55Z | - |
dc.date.available | 2022-06-17T00:09:55Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | http://repository.ipb.ac.id/handle/123456789/112081 | - |
dc.description.abstract | SARS-CoV-2 menyebabkan sindrom pernafasan akut dan telah menginfeksi banyak korban dari berbagai negara. SARS-CoV-2 menggunakan RNA-dependent RNA polymerase untuk melakukan replikasi dan transkripsi genom virus. Tanaman gmelina dapat dimanfaatkan sebagai obat tradisional. Penelitian bertujuan menganalisis interaksi senyawa alami kulit kayu gmelina (Gmelina arborea Roxb) dalam menghambat enzim RNA-dependent RNA polymerase SARS-CoV-2 melalui penambatan molekuler serta menganalisis sifat farmakokinetik dan toksisitas senyawa. Gmelinol (∆G -6.192 kkal/mol) lebih unggul dibanding ligan uji lainnya berdasarkan nilai energi bebas ikatan, interaksi dengan residu aktif, dan analisis Lipinski. Hasil prediksi ADME menyatakan bahwa gmelinol berperan sebagai substrat dan inhibitor CYP3A4. Hasil prediksi toksisitas oral menyatakan bahwa gmelinol termasuk senyawa kelas IV yang berarti berbahaya jika tertelan. | id |
dc.description.abstract | SARS-CoV-2 causes acute respiratory syndrome and has infected many people in various countries. SARS-CoV-2 uses an RNA-dependent RNA polymerase enzyme for replication and transcription of the viral genome. Gmelina plants can be used as traditional medicine. This study aimed to analyze the interaction of natural compounds in the gmelina bark (Gmelina arborea Roxb) in inhibiting the enzyme of SARS-CoV-2 RNA-dependent RNA polymerase by molecular docking, analyze the pharmacokinetic properties, and toxicity. Gmelinol (∆G -6.192 kcal/mol) was better than other ligands based on binding free energy, interactions with active residues, and Lipinski analysis. ADME prediction stated that gmelinol acts as a substrate and inhibitor of CYP3A4. Oral toxicity prediction stated that gmelinol is a class IV compound which harmful if swallowed. | id |
dc.language.iso | id | id |
dc.publisher | IPB University | id |
dc.title | Studi In silico Senyawa Alami Kulit Kayu Gmelina arborea terhadap RNA-dependent RNA polymerase SARS-CoV-2 | id |
dc.type | Undergraduate Thesis | id |
dc.subject.keyword | gmelina | id |
dc.subject.keyword | gmelinol | id |
dc.subject.keyword | molecular docking | id |
dc.subject.keyword | RNA-dependent RNA polymerase | id |
dc.subject.keyword | SARS-CoV-2 | id |
Appears in Collections: | UT - Biochemistry |
Files in This Item:
File | Description | Size | Format | |
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Cover, Lembar Pengesahan, Prakata, Daftar Isi.pdf Restricted Access | Cover | 685.23 kB | Adobe PDF | View/Open |
G84180028_Pertiwi Werdiningsih.pdf Restricted Access | Fullteks | 2.4 MB | Adobe PDF | View/Open |
Lampiran.pdf Restricted Access | Lampiran | 982.28 kB | Adobe PDF | View/Open |
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