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Title: | Sintesis dan Karakterisasi Scaffold Komposit HA-CHA/Kolagen/Alginat dan HA-CHA/Kolagen/PVA/Alginat |
Other Titles: | Synthesis and Characterization of HA-CHA/Collagen/Alginate and HA-CHA/Collagen/PVA/Alginate Composite Scaffolds |
Authors: | Sari, Yessie Widya Kurniati, Mersi Naeli, Zurotun |
Issue Date: | 2022 |
Publisher: | IPB University |
Abstract: | Metode pencangkokan tulang yang sudah dikenal saat ini diantaranya yaitu
autograft, allograft, dan xenograft. Meskipun metode tersebut terbukti dapat
memperbaiki suatu jaringan tulang yang rusak, namun metode ini masih memiliki
banyak keterbatasan yang dapat menyebabkan terhambatnya proses pengobatan.
Salah satu upaya untuk mengatasi keterbatasan tersebut yaitu dengan
dikembangkannya bone graft sintetis (scaffold). Fokus penelitian ini yaitu
menyintesis scaffold komposit HA-CHA/Kolagen/Alginat dan HA CHA/Kolagen/PVA/Alginat menggunakan metode freeze-drying. Scaffold dibuat
dengan memvariasikan komposisi komponen anorganik (HA, CHA) dan komponen
organik (polimer) dengan rasio perbandingan anorganik:organik yaitu 25:75, 50:50,
75:25 dan HA:CHA masing-masing 100:0, 75:25, 50:50, 25:75, 0:100. Hasil
sintesis kemudian dikarakterisasi menggunakan SEM-EDX, FTIR, dan XRD. Hasil
SEM menunjukkan scaffold komposit HA-CHA/Kolagen/Alginat memiliki struktur
morfologi cukup teratur dan pori-pori yang terbentuk tampak jelas, sedangkan
scaffold komposit HA-CHA/Kolagen/PVA/Alginat memiliki struktur morfologi
yang tidak teratur dan pori-pori tampak halus. Hasil pengujian EDX menunjukkan
sebagian besar scaffold tersusun atas unsur karbon (C), oksigen (O), kalsium (Ca),
dan fosfor (P). Hasil uji FTIR menunjukkan adanya keidentikan senyawa yang
dihasilkan dan tidak terbentuk gugus fungsi baru. Hasil analisis XRD menunjukkan
semakin besar kandungan organik dalam sampel akan memperkecil ukuran kristalit
dan derajat kristalinitas dari scaffold. The methods of bone grafting that are known today are autograft, allograft, and xenograft. Although these method is proven to repair damaged bone tissue, but these techniques still have many limitations that can lead to inhibition of the treatment process. These limitations can be overcome by using a synthetic bone graft (scaffold). The focus of this study is synthesizing HA-CHA/Collagen/Alginate and HA-CHA/Collagen/PVA/Alginat composite scaffold using freeze-drying methods. Scaffold made by varying the composition between inorganic components (HA, CHA) and organic components (polymers) with inorganic:organic ratio is 25:75, 50:50, 75:25 and HA:CHA respectively 100:0, 75:25, 50:50, 25:75, 0:100. The synthesis results are characterized by SEM-EDX, FTIR, and XRD. The SEM results showed that the HA-CHA/Collagen/Alginate composite scaffold has a fairly regular morphological structure and the pores formed are clearly visible, while the HA-CHA/Collagen/PVA/Alginate composite scaffold has an irregular morphological structure and the pores look smooth. The EDX results test showed that most scaffolds are composed of the elements carbon (C), oxygen (O), calcium (Ca), and phosphorus (P). The results of the FTIR test showed the compounds produced are identical and do not form a new functional group. The results of XRD analysis showed that the greater organic content in the sample will reduce the size of the crystalline and crystallinity of the scaffold. |
URI: | http://repository.ipb.ac.id/handle/123456789/111308 |
Appears in Collections: | UT - Physics |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Cover, Lembar Pengesahan, Prakata, Daftar Isi.pdf Restricted Access | Cover | 327.17 kB | Adobe PDF | View/Open |
G74170026_Zurotun Naeli.pdf Restricted Access | Fullteks | 1.27 MB | Adobe PDF | View/Open |
Lampiran.pdf Restricted Access | Lampiran | 1.31 MB | Adobe PDF | View/Open |
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