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http://repository.ipb.ac.id/handle/123456789/111104
Title: | Penambatan Molekuler Senyawa Aktif Sirih Merah (Piper crocatum) sebagai Inhibitor Angiotensin Converting Enzyme |
Authors: | Seno, Djarot Sasongko Hami Safithri, Mega Irsal, Riyan Alifbi Putera |
Issue Date: | 2022 |
Publisher: | IPB University |
Abstract: | Hipertensi merupakan penyakit yang disebabkan tekanan arteri tinggi yang tidak normal yaitu diatas 140/90. Dua pertiga orang dewasa di dunia menderita penyakit ini dan di Indonesia sudah semakin meningkat dari umur di atas 18 tahun. Lisinopril (Angiotensin Converting Enzyme inhibitor) menjadi obat pilihan di lini pertama dalam menangani hipertensi, namun obat tersebut masih memberikan banyak efek samping. Sirih merah telah banyak digunakan dalam pengobatan herbal dan diharapkan berpotensi menghambat aktivitas ACE (Angiotensin Converting Enzyme). Penelitian ini bertujuan menemukan senyawa aktif yang berpotensi menginhibisi ACE secara in silico dengan metode penambatan molekuler. Hasil penelitian menunjukkan 8 dari 83 senyawa aktif sirih merah. Senyawa aktif 3S, 5R, 8R, 9R, 10R, 12R, 13R, 14R, 17S)-17-[(2S)-5-[2-(3,4-dimethoxyphenyl) ethylamino]-2-hydroxypentan-2-yl]-4,4,8,10,14-pentamethyl-2, 3, 5, 6, 7, 9, 11, 12, 13, 15, 16, 17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol adalah metabolit sekunder berjenis alkaloid yang berpotensi dalam inhibisi ACE dengan nilai energi bebas ikatan (∆G) 9.958 kkal/mol dan berinteraksi dengan 17 residu asam amino. Hasil penelitian dapat digunakan sebagai acuan dalam studi lebih lanjut. Hypertension is a disease caused by abnormally high arterial pressure above 140/90. Two thirds of adults in the world suffer from this disease and in Indonesia has been increasing from the age of 18 years. Lisinopril (Angiotensin Converting Enzyme (ACE) inhibitor) is the drug of choice in the first line in treating hypertension, but the drug still has many side effects. Red betel has been widely used in herbal medicine and is expected to potentially inhibit ACE activity. This study aims to find the active compound that has the potential to inhibit ACE in silico through molecular docking method. The results showed 8 out of 83 active compounds of red betel. The active compound 3S,5R,8R,9R,10R,12R,13R,14R, 17S)-17-[(2S)-5-[2-(3,4-dimethoxyphenyl) ethylamino]-2-hydroxypentan-2-yl]-4,4,8,10,14-pentamethyl-2, 3, 5, 6, 7, 9, 11, 12, 13, 15, 16, 17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol is an alkaloid type secondary metabolite that has the potential for ACE inhibition with a bond free energy value (∆G) of 9.958 kcal/mol and interacts with 17 amino acid residues. The research results can be used as a reference in further studies. |
URI: | http://repository.ipb.ac.id/handle/123456789/111104 |
Appears in Collections: | UT - Biochemistry |
Files in This Item:
File | Description | Size | Format | |
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Cover, Lembar Pengesahan, Pustaka, Daftar Isi.pdf Restricted Access | Cover | 386.85 kB | Adobe PDF | View/Open |
Riyan_Skripsi Full Text.pdf Restricted Access | Full Text | 1.57 MB | Adobe PDF | View/Open |
Lampiran.pdf Restricted Access | Lampiran | 819.18 kB | Adobe PDF | View/Open |
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