Please use this identifier to cite or link to this item: http://repository.ipb.ac.id/handle/123456789/109295
Title: Karakterisasi Gen ADAM10 sebagai Marka Molekuler Alzheimer pada Otak Monyet Ekor Panjang (Macaca fascicularis)
Other Titles: Characterization of ADAM10 gene as the Molecular Marker of Alzheimer on Cynolmogus Monkey’s Brain
Authors: Darusman, Huda Shalahudin
Ilyas, Abdul Zahid
Lusiana, Devi
Issue Date: 2021
Publisher: IPB University
Abstract: Demensia merupakan gangguan pada memori, kemampuan kognitif dan perilaku. Terdapat 47 juta kasus di tahun 2015 dengan biaya penanganan yang mencapai 818 milyar Dollar Amerika Serikat secara global. Alzheimer merupakan penyumbang kasus demensia terbesar sehingga diperlukan pemahaman secara molekuler yang lebih mendalam untuk mempermudah mengatasi penyakit ini. Monyet ekor panjang yang memiliki kemiripan dengan manusia dipilih sebagai hewan model. Penelitian ini bertujuan untuk memahami lebih dalam mengenai ekspresi gen ADAM10 di otak serta potensinya sebagai marka molekuler penyakit Alzheimer. Sampel diekstrasi dari hipokampus dan korteks 9 ekor monyet betina. Pendeteksian level ekspresi mRNA ADAM10 di otak dilakukan dengan RT-qPCR. Hasil menunjukkan tidak ada beda nyata antara ekspresi mRNA ADAM10 pada kelompok Tua dan Dewasa serta pada regio hipokampus dan regio korteks. Namun, hasil perhitungan menujukkan kecenderung lebih tinggi pada monyet dari kelompok Tua dibanding kelompok Dewasa dan cenderung lebih tinggi di hipokampus daripada korteks dari seluruh sampel. Level ekspresi mRNA ADAM10 dianggap tetap berpotensi menjadi marka molekuler penyakit Alzheimer.
Dementia is an impairment found in memory, cognitive functions, and behavior. There were 47 million cases of dementia and the treatment cost 818 billion USD globally in 2015. Alzheimer’s diseade (AD) is the biggest cause of dementia, thus it is important to have deeper understanding in molecular level to be able to treat this disease. Cynomolgus monkey were chosen because of the similarities between them with human. This study aimed to have more understanding about ADAM10 gene expression in the brain and its potential as molecular marker of Alzheimer’s disease. Samples were extracted from hippocampus and cortex of the brain of each 9 female monkeys. The detection of ADAM10 mRNA expression level was done using the RT-qPCR method. The results showed no significant differences in the expression between Old group and Adult group and also between hippocampus and cortex. However, the expression level tended to be higher in the Old group and the hippocampus. ADAM10 mRNA expression level is still considered as the potential molecular marker for AD.
URI: http://repository.ipb.ac.id/handle/123456789/109295
Appears in Collections:UT - Anatomy, Phisiology and Pharmacology

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Cover, Lembar Pernyataan, Abstrak, Lembar Pengesahan, Prakata, Daftar Isi.pdf
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B04170077_Devi Lusiana.pdf
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Lampiran.pdf
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Lampiran327.32 kBAdobe PDFView/Open


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