Please use this identifier to cite or link to this item: http://repository.ipb.ac.id/handle/123456789/105901
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dc.contributor.advisorHasan, Akhmad Endang Zainal-
dc.contributor.advisorAndrianto, Dimas-
dc.contributor.authorPrayoga, Galuh Rizal-
dc.date.accessioned2021-02-14T08:08:14Z-
dc.date.available2021-02-14T08:08:14Z-
dc.date.issued2021-
dc.identifier.urihttp://repository.ipb.ac.id/handle/123456789/105901-
dc.description.abstractSekitar lebih 70% kasus kanker payudara adalah tipe positif hormon reseptor. Kasus kanker payudara tipe ini lebih banyak terjadi pada wanita post menopaus. Pengobatan yang efektif kasus ini adalah pemberian inhibitor enzim aromatase. Senyawa isoflavonoid batang Spatholobus suberectus telah teruji secara in vitro memiliki aktivitas sitotoksik terhadap sel kanker payudara MCF-7 yang banyak mengekspresikan reseptor estrogen dan enzim aromatase. Perlu dilakukan pencarian senyawa lain batang Spatholobus suberectus yang berpotensi memiliki aktivitas antikanker payudara. Penelitian ini bertujuan memprediksi potensi senyawa-aktif batang Spatholobus suberectus sebagai antikanker payudara melalui mekanisme penghambatan enzim aromatase secara in silico dengan metode penambatan molekular. Simulasi penambatan molekuler dilakukan melalui parameter energi ikat (ΔG), konstanta inhibisi (Ki), jenis interaksi dan binding site similarity (BSS). Senyawa aktif yang diprediksi memiliki potensi adalah prestegane B, 2R,3R-3,7-dihidroksiflavanon, dihidrorobinetin, asam protokatekuat etil ester, liquiritigenin, naringenin, 7,4’-dihidroksi-8-metoksi-isoflavone, asam protokatekuat, glisirosida, dulcisflavan, butein, hesperetin, plathymenin, isoliquiritigenin, dan medioresinol.id
dc.description.abstractApproximately over 70% of breast cancer cases are positive types of hormone receptors. Cases of this type of breast cancer are more common in post menopausal woman. An effective treatment of this case is the administration of aromatase enzyme inhibitors. The stem isoflavonoid compound Spatholobus suberectus has been tested in vitro has cytotoxic activity against MCF-7 breast cancer cells that expressed a lot of estrogen receptors and aromatase enzymes. It is necessary to search for other compounds of Spatholobus suberectus stem that have the potential to have anticancer activity of the breast. This study aimed to predict the potential of compound-active stem Spatholobus suberectus as an anticancer breast through the mechanism of inhibition of aromatase enzymes in silico by molecular docking method. Molecular tethering simulation is done through binding energy parameters (ΔG), inhibition constants (Ki), types of interaction and binding site similarity (BSS). Active compounds that was predicted to have potential are prestegane B, 2R,3R-3,7-dihydroxyflavanon, dihydrorobinetin, protocatechuic acid ethyl ester, liquiritigenin, naringenin, 7,4’-dihidroksi-8-metoksi-isoflavone, protocatechuic acid, glyciroside, dulcisflavan, butein, hesperetin, plathymenin, isoliquiritigenin, and medioresinol.id
dc.language.isoidid
dc.publisherIPB Universityid
dc.titleAktivitas antikanker payudara senyawa aktif asal batang Spatholobus suberectus secara in silicoid
dc.title.alternativeActivity of breast anticancer of active compound from Spatholobus suberectus stem’s by in silicoid
dc.typeUndergraduate Thesisid
dc.subject.keywordmolecular dockingid
dc.subject.keywordinhibitorid
dc.subject.keywordaromataseid
Appears in Collections:UT - Biochemistry

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