Farmakologi Balik dan Jejaring untuk Pencarian Senyawa Aktif dari Jamu Antidiabetes

Abstract

One of the attempts to treat diabetes is by using herbal medicines. The explanation of molecular mechanism from medicinal plant (herb) compounds such as their interaction with target proteins still to be developed. The aims of the research are to find potential active compounds from antidiabetic medicinal plants, to find their molecular mechanism of inhibition, and to check potentiality of herbal formula plants as antidiabetic through study of reversed and network pharmacology. Antidiabetic potential compounds and molecular mechanism were discovered by analyzing networks formed between compounds of clinical trial plants, lead compounds such as antidiabetic standards, and compounds of herbal formula plants. There are 10 potential compounds obtained from networks and further evaluated for their drug-likeness using the rule of five. The evaluation revealed 8 compounds that meet the rule and further confirmed their activity on the target through molecular docking. The result of docking showed that 3,4- dihydroxybenzoic acid, berberine, and (-)-secoisolariciresinol gave better affinity than that of the target protein‟s inhibitor standard, thus these compounds are potential to play a role in the treatment of diabetes.