Inhibitor Tirosinase Ekstrak Metanol Berbagai Bagian Pohon Jabon dan Mangium

Abstract

Jabon and mangium are currently planted in community forest. The wastes resulted from the utilization of forest products can reach 75%, including leaves barks, and woods. One of the ways to increase value of those wastes can be done by utilizing the extractive compounds contained in wood waste as tyrosinase inhibitor. Parts of tree which were extracted consist of leaves, barks, sapwood, and heartwood. The extraction method used in this research was soxhletation using methanol for 12 hours. The yield of extracts was 0.89-13.02%, with the lowest yield from sapwood of mangium and the highest was resulted by jabon’s leaves. Mangium bark extract had the highest activity as inhibitors of tyrosinase, with the value of IC50 was 129.81 ppm for the monophenolase reaction or three times higher than kojic acid (38.45 ppm) and 240.88 ppm for the diphenolase reaction or two times higher than kojic acid (102.11 ppm). The compounds contained within mangium bark extracts were expected to be inhibitor of tyrosinase, which was classified to flavonoids.