Pengaruh Pemberian Infusa Biji Adas (Foeniculum vulgare Mill.) terhadap Perkembangan Folikel Ovarium Tikus Putih (Rattus norvegicus) Produktif dan Premenopause

Abstract

Fennel (Foeniculum vulgare Mill.) knows contain phytoestrogens, the chemical substances that have effect as well as estrogen hormones. This research aimed to determine the effect of fennel infusion treatment on various doses to development of ovarian follicles of productive and premenopausal white rats (Rattus norvegicus). Twenty five productive rats and 25 premenopausal rats each were divided into 5 groups, i.e. negative control group (KN) which were treated by 1 ml of aquades, positive control group (KP) which were treated by etinil estradiol 9x10-3 mg/200 g of body weight (BW), Doses 1 group (D1) was treated by 36.5 mg/100 g of BW fennel infusion, Doses 2 group (D2) was treated by 75 mg/100 g of BW fennel infusion and Doses 3 (D3) were treated by 146 mg/100 g of BW fennel infusion. The infusion fennel treatment was done by force feeding method for 16 days. The results showed that the treatment of fennel infusion for all groups for 16 days had no effect on the development of ovarian follicles.