Studi Komponen Aktif Temu Lawak terhadap Patogenesis Kanker Kolorektum Jalur Protein β-Katenin dengan Penambatan Molekular

Abstract

Chemotherapy of colorectal cancer can be carried out by inhibiting the activity of excessive β-catenin protein in the body with anticancer compounds. One of the potential plants as anticancer is temu lawak (Curcuma xanthorrhiza). The molecular docking method can be used to determine the potential activity and efficiency of temu lawak bioactive compounds to inhibit the colorectal cancer through β-catenin protein pathway. The docking results of 24 active components in temu lawak against 14 proteins in β-catenin pathway obtained 3 potential bioactive anticancer compounds, namely dihydrocurcumin, demethoxycurcumin, and curcumin. The bioactive compounds could inhibit the colorectal cancer through the axin protein in β-catenin pathway. The interaction were observed based on several parameters: Gibbs free energy (ΔG), affinity (pKi), inhibition constant (Ki), efficiency, and hydrogen bonding. The results from the docking process were better compared with the XAV939 and IWR standards which have been known as inhibitors of colorectal cancer in axin protein.