Stability of Ketoprofen Microcapsule Coated with Chitosan-Alginat

Abstract

Drug preparations for stability test has been done in previous research, with composition of chitosan 1.75% (w/v), alginate 0.625% (w/v), glutaraldehyde 4.5% (v/v), and ketoprofen 0.8% (w/v), added with Tween 80 of three levels (1, 2, 3 %). All mixtures were shook under three different times (1, 2, 3 hours). As a new drug preparation, the stability of ketoprofen microcapsule need to be studied. The purpose is to measure the resistance of the coat during storage and use. The stability was tested using accelerated method in climatic chamber under 40±2 °C and relative humidity of 75±5 % in 3 months. The parameter was measured every week included moisture content by using moisture analyzer and ketoprofen content using ultraviolet spectrophotometer at wavelength 254.7 nm. All nine formulas showed high (>10%) and fluctuating moisture content while ketoprofen content was decreasing following different reaction kinetics model for each formula, formula 1 and 2 followed second order, formula 3, 4, 5, 6, 7, 9 followed kinetics Avrami-Erofeev model, and formula 8 followed Prout-Tompkins kinetics model. Microcapsules of formula 8 added with Tween 80 3% and shook for 2 hours, was relatively the best, with ketoprofen content percentage still coated after 3 months, degradation rate constant, and shelf life of 91.47%, 0.0875 week-1, and 14.01 week, respectively. The degradation of ketoprofen presumably follow autocatalytic reaction mechanism controlled by formation and growth of reaction core.