Optimasi dan Evaluasi Mikroenkapsulasi Medroksiprogesteron Asetat Tersalut Poli(ε-kaprolakton)-Lilin Lebah

Abstract

One of techniques to encapsulate drugs with polymer material is microencapsulation. Encapsulation can be used to control release of drugs, so the side effect can be reduced. In this research, medroxyprogesterone acetate (MPA) was coated by poly(ε-caprolactone) (PCL) and beeswax. The emulsification-solvent evaporation was used to make MPA microcapsules with various ratio of PCL to beeswax of 7:3, 8:2, and 9:1 and concentration of poly(vinyl alcohol) emulsifier were 1%, 2%, and 3%. The highest microcapsule efficiency was 83.47% in microcapsule with the ratio of PCL to beeswax was 9:1 and 3% concentration of PVA. The release kinetics of MPA followed Korsmeyer-Peppas kinetic modeling with super case-II transport as drug release mechanism. Microcapsule that resulted in this research have particle size 67–144 μm with homogeneous dispersion of the core in the polymer matrix.