Pengaruh Ekstrak Akar Kayu Kuning (Coscinium fenestratum) dengan Pelarut Etanol Terhadap Gambaran Leukosit Mencit yang Diinfeksi Plasmodium berghei

Abstract

The research was aimed to determine the effect of Coscinium fenestratum root extracts with ethanol solvent on leucocyte profile in mice infected with Plasmodium berghei. This research used 25 male mices that infected with P. berghei and divided into five groups of mice with five mices in each group, 1) Negative Control (given with Pulvis Gum Arabic soluble), 2) Positive Control (given with chloroquine), 3) E1 (ethanol extracts C. fenestratum with dosage 0.625 mg/25 gr BB), 4) E2 (ethanol extracts C. fenestratum with dosage 1.25 mg/25 gr BB), 5) E3 (ethanol extracts C. fenestratum with dosage 3.75 mg/ 25 gr BB). The research was used completely randomized design with five times repetition. The result showed that C. fenestratum root extracts with ethanol, the neutrophil percentage in all treatment was lower than negative control until 7th day after given extract. The eosinophil percentage was not show significant defferent. The monocyte percentage all treatment was lower than negative control at 2nd day until 7th day after given extract. The lymphocyte percentage all treatment was higher than negative control until 7th day after given extract. The basophil percentage in all treatment was not show significant defferent with negative control.