Gambaran Histopatologi Hati dan Ginjal Tikus Laktasi yang Diberi Ekstrak dan Fraksi Sauropus androgynus (L.) Merr Sejak Bunting Sampai 10 Hari Postpartus

Abstract

This study was aimed to obtain the information about the possibility of side effects (toxic) from consuming of katuk (Sauropus androgynus) leaf extract and fractions using rats as experimental animals. Fifteen pregnant female rats were divided into 5 treatment groups; control (K), ethanol crude exstract (EEtOH), hexan fraction (F-H), ethylacetate fraction (F-EtAc), and water fraction (- FH2O). The katuk leaf extract and fraction were fed from the beginning of pregnancy until 10 days postpartus. Histopathological assay was conducted to investigate the effect of treatment to the liver and kidneys at 10 days postpartus. Histopathology of liver showed that the katuk leaves extract group F-H2O, F-EtAc, and E-EtOH are able to protect the hepatocyts of the liver from apoptosis, but the katuk leaves extract or their metabolites tended to increase the number of apoptosis on renal tubular epithelium of the kidneys. For both organs, the result indicated that the group of katuk leaves water fraction (F-H2O) treatment cause the minimal damage among the others.