Kajian Toksikopatologi Ekstrak Eter Daun Kelor (Moringa oleifera Lamk.) pada Mencit Putih (Mus musculus albinus)

Abstract

The purpose of this study is to examine the loxicopathological effect of ether extract MOrin,a oleikra Lamk. Leaf were given to mice orally for j consecutive cWys. The toxicopathological study was conducted based on the gross and histopatological lesion of lhe internal organ include brain, lungs, heart, stomach, intestine, spleen and kidney. Twenty DDY strain mice, male, age 2 to 3 months old with 18-30 grams weight were devided into four groups. There were the control groups and 3 treatment groups which received 2,5%, 5%, 10% LD50 (Lethality Dose 50) dose ~f ether extract Moringa oleifera Lamk. The LD50 dosein mice was obtainedfrom the previous study accounledfor 16,89 grl kg body weight. Gross lesion only observed within liVer of group IV mice which showed black spot.'i. Histopathologically in group IV, there were mild congestion in brain, necrosis within liver, protein deposition in tubules and glomerular, goblet cell of bronchiole epithelium increased1n group III there were protein deposition in tubules and glomerular. There were no Significantly difference among the groups in the heart, stomach, intestine and spleen microscopical lessiom. The study concluded that 10% W50 of ether extract of Moringa ole/rera Lamk. leaf had toxic effect to the liver, kidney, lungs and cerebrom. Five percent of W50 dose of Moringa oleifera Lamk. give a loxical effect to the kidney, while the dose of 2,5 % LD50 was seem to be a save concentration for consumption.