Kajian Morfologi Proses Persembuhan Kerusakan Segmental Pada Tulang Domba Yang Diimplan Dengan Komposit Hidroksiapatit-Kitosan (HA-K)

Abstract

This research was aimed to study the morphology of healing process on sheep’s bone implanted with hydroxyapatite-chitosan (HA-C) composite. This research would also present information about the potency of HA-C composite as synthetic bone graft biomaterial or bone implant. Three local sheeps were used in this study. HA-C composite was implanted on the medial of the left tibia bone while the same part of right tibia was treated as control without implant. All implant were harvested at 30, 60, and 90 days post-operation. The observation parameters were the condition, shape, and degradation degree of the implant, bonding between implant and host bone, new bone ingrowth into the implant, and signs of inflammation reaction around the implant. The result showed that the healing process on control bone was faster than those of the implanted bone. As far as 90 days observation in this present study was concerned, HA-C implant did not show characteristics for biodegradability, bioresorbability, osteoconductivity, and bioactivity. However, it showed biocompatibility properties for host body. It is suggested that the implant used in this study is more suitable to be developed as synthetic bone graft biomaterial for application on large defects with healing time longer than 90 days.