In Vitro antimycotic activity of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb. against opportunistic filamentous fungi

Abstract

Xanthorrhizol was isolated from the rhizome of Curcuma xanthorrhiza (Zingiberaceae) and its in vitro activity against opportunistic filamentous fungi was evaluated using the NCCLS (M38-A) standard method. Xanthorrhizol was found to be active against all the species tested, namely Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger, Fusarium oxysporum, Rhizopus oryzae and Trichophyton mentagrophytes: the MICs being 2.0, 2.0, 2.0, 4.0, 1.0 and 1.0 µg/mL, while the MFCs were 4.0, 4.0, 4.0, 8.0, 2.0 and 2.0 µg/mL, respectively. The susceptibility of six species of filamentous fungi to xanthorrhizol was comparable to that of the commercial antifungal, amphotericin B. Xanthorrhizol also has activity to inhibit the conidial germination of all tested species. The results strongly suggest that xanthorrhizol can be developed as a natural antifungal agent. Copyright © 2007 John Wiley & Sons, Ltd. ________________________________________ Received: 7 August 2006; Accepted: 20 November 2006 Keywords antifungal • in vitro • opportunistic fungi • xanthorrhizol