CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans
Date
2010Author
Heather L. Davis
Suparto, Irma
Weeratnaa, Risini
Jumintartod
Iskandriatic, Diah
Pawitri, Dyah
Chamzaha, Siti
Ma'rufd, Amir
Nented, Citrakasih
Pawitric, Dyah
Arthur M. Krieg
Heriyantod
Willie Smits
Sajuthi, Dondin
Metadata
Show full item recordAbstract
Oligonucleotides containing immunostimulatory CpG motifs (CpG ODN) have been shown to be potent Th1-type adjuvants for augmenting antigen-specific responses in mice against hepatitis B surface antigen (HBsAg). The hepatitis B virus (HBV) infects only humans and great apes and appears to exist among wild chimpanzees and orangutans. An outbreak of HBV among orangutans being rehabilitated for re-introduction to the jungle caused the death of several animals. A prophylactic vaccination program revealed that orangutans are quite hypo-responsive to a current commercial vaccine compared to results obtained previously in humans and chimpanzees. Addition of CpG ODN to hepatitis B vaccine greatly increased the seroconversion rate and the titers of antibody against HBsAg (anti-HBs). This is the first demonstration of CpG DNA in a great ape and the results have important implications for the vaccination of humans against HBV and other diseases. Author Keywords : Non-human primate; Infectious immunity — virus; Hepatitis B vaccine; Adjuvant