Kajian Pakan Bersumber Energi Tinggi pada Pembentukan Monyet Obes

Abstract

Obesity is a primary predisposition for diseases such as metabolic syndrome (such as insulin resistance, blood lipid abnormality, and hypertension), type 2 diabetes, and cardiovascular disease. The effort to overcome obesity is needed by understanding develop of obesity. Therefore, it is urgent to carry out preclinical trials by using an obese animal model. The objective of this research was to study the high energy feed with animal fat and carbohydrate to produce obese cynomolgus monkeys (Macaca fascicularis). Animals used in this study were 15 adult males divided equally into three treatment groups; 1) receiving feed A consist of beef tallow without egg yolk (energy 4,207 cal/g, fat 19.62%, and starch 60.34%); 2) receiving feed B consist of beef tallow and egg yolk, (energy 4,207 cal/g, fat 19.62%, and starch 60.34%) 3) receiving feed C, monkey chow as control (energy 4,330 cal/g, EE 5.55%, and NFE 51.38%). Measurement were carried out every four weeks for body weight gain, sitting height gain, hip diameter, abdominal thickness, body mass index, feed and nutrient consumption, and feed digestibility. Results showed that there was significant (p<0.05) body weight gain in week- 4 and 8. Based on the average difference test, it was known that feed B was resulting the highest (p<0.05) body gain compared to feed A and C. For the body measurement, the monkeys with feed B were bigger (p<0.05) than feed A and C. Therefore, it was considered as obese in terms of body mass index. Protein digestibility in feed A and B was lower (p<0.05) compared to C. However, digestibility in dry matter, fat, starch and energy were about 90%, meaning that the rations were considered good in making obese monkey. The feed formula containing tallow and egg yolk could increase body weight resulting in a positive correlation toward body measurement and body mass index.