The Dynamic of HIV Virus Infection as a Result of Protease Inhibitor Therapy.

Abstract

Acquired immunodeficiency syndrome (AIDS) is defined as symptoms of deterioration human immune system caused by human immunodeficiency virus (HIV). The virus damages the leucocytes; therefore, once a person infected by the HIV, his/her immune system will be paralyzed and eventually will not be able to survive from any disease. HIV is transmitted in many ways, such as having unsafe sex, using unsterilized syringe, blood transfusion, and many more. So far, there has not been discovered yet a way or a medicine that can totally cure this disease. However, reverse transcriptase inhibitor therapy, protease inhibitor, or combination of those two can decline the growth of virus inside the body of the infected person. Therefore, the immune system will be enhanced back to normal phase. In this paper, will analyze the effect of protease inhibitor therapy on the dynamics of virus inside the blood with different value of effectiveness. There are two mathematical models of protease inhibitor therapy to consider, i.e. perfect and imperfect protease inhibitor. The perfect protease inhibitor therapy hinders the virus to grow well and not to infect healthy leucocytes. On the other hand, the imperfect one cannot completely detained the virus growth.