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      • UT - School of Veterinary Medicine and Biomedical Science
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      Efektivitas Infusa Umbi Bawang Merah (Allium cepa L.) sebagai Antidiare Tikus Pediatri (Rattus norvegicus).

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      Date
      2024
      Author
      Andre, Daniel Latief
      Pristihadi, Diah Nugrahani
      Widyananta, Budhy Jasa
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      Abstract
      Penyakit diare menjadi salah satu masalah kesehatan masyarakat baik di Indonesia maupun dunia. Upaya penanggulangan diare dapat dilakukan dengan obat modern dan obat tradisional. Penelitian ini bertujuan mengetahui efektivitas terbaik antidiare dari umbi bawang merah (Allium cepa L.) pada tikus pediatri. Metode transit intestinal dilakukan dengan tikus diberikan minyak jarak dan perlakuan (kontrol negatif, kontrol positif, dan infusa umbi bawang merah pada konsentrasi 1,25%, 2,5%, 5%, dan 10%) secara peroral. Kemudian tikus diberikan tinta cina secara peroral dan dilakukan pembedahan ruang abdomen setelah dianestesikan. Lalu dihitung rasio jarak antara panjang usus yang dilalui tinta cina dibandingkan dengan panjang usus total. Data-data yang diperoleh dianalisis dengan metode Analysis of Variance (ANOVA). Hasil menunjukkan infusa umbi bawang merah dapat menghasilkan efek antidiare pada tikus pediatri dengan konsentrasi 2,5 dan 5%. Sediaan infusa umbi bawang merah memiliki efektivitas sebagai antidiare dengan senyawa-senyawa yang terkandung di dalamnya (flavonoid, tannin, dan saponin). Sebagai kesimpulan, konsentrasi 5% efektif untuk mengatasi diare pada tikus pediatri.
       
      Diarrheal disease has become one of the public health issues both in Indonesia and worldwide. Efforts to combat diarrhea can be carried out using modern medicine as well as traditional remedies. This study aims to determine the best effectiveness of the shallot bulb (Allium cepa L.) as an antidiarrheal agent in young rats. Intestinal transit method is conducted with the rats are administered castor oil and some treatments (negative control, positive control, and shallot bulb infusion at concentrations of 1,25%, 2,5%, 5%, and 10%) orally. Furthermore, the rats are orally administered Chinese ink and undergo abdominal surgery after being anesthetized. The ratio of the distance that the Chinese ink traveled through the intestines is then measured compared to the total length of the intestines. The collected data are analyzed using Analysis of Variance (ANOVA) method. The results show that the shallot bulb infusion could produce an antidiarrheal effect in young rats at concentrations of 2,5% and 5%. The shallot bulb infusion formulation has effectiveness as an antidiarrheal agent due to its compounds in it (flavonoids, tannins, and saponins). In conclusion, the 5% concentration is effective to overcome diarrhea in pediatric rats.
       
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      http://repository.ipb.ac.id/handle/123456789/153589
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      • UT - Anatomy, Phisiology and Pharmacology [1047]

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