Histopatologi hati ayam yang diinfeksi Ascaridia galli dan diobati ekstrak etanol akar daruju [Acanthus ilicifolius Linn.]

Abstract

The aim of this research is to examine the histopathological changes of chicken liver treated by 70% ethanol extract of Acanthi radix as the anthelmintic against Larva-3 A. galli. Eighteen chickens were divided into six groups, which were control group (without any treatment), negative control group (without medicinal treatment), positive control group treated by pyrantel pamoate 54.25 mg/kg BW, treated groups by 70% extract of Acanthi radix which doses were 124 mg/kg BW, 248 mg/kg BW and 496 mg/kg BW, per oral for 3 days. The result of liver histopathological evaluation showed hydropic degeneration and apoptosis of hepatocytes on every group observed. The hydropic degeneration was not significantly different (p>0.05) among the groups. This research also showed that apoptosis of groups treated by extract of Acanthi radix were significantly higher (p<0.05) than pyrantel pamoate group. The treatment of 70% ethanol extract of Acanthi radix tends to make apoptosis of hepatocytes but still in mild changes. Keywords: Acanthi radix, A. galli, extract, chicken liver, histopathology, toxicity.