Aktivitas Infusa Temu Putih (Curcuma zedoaria) pada Tikus Putih Sprague Dawley yang diinduksi Gastritis

Abstract

Gastritis dapat diartikan sebagai penyakit yang terjadi karena peradangan pada lapisan mukosa maupun submukosa lambung. Kandungan infusa temu putih (Curcuma zedoaria) antara lain kurkumin, flavonoid, minyak atsiri, dan polifenol belum banyak diteliti sebagai gastroprotektif. Penelitian ini bertujuan membuktikan efek gastroprotektif infusa temu putih (Curcuma zedoaria) terhadap tikus Sprague Dawley yang diinduksi HCl dan etanol. Sebanyak 16 ekor tikus dibagi menjadi empat kelompok perlakuan dan dipuasakan selama 18 jam terlebih dahulu. Kelompok negatif (KN) hanya diberikan induksi gastritis campuran HCl dan etanol, kelompok positif (KP) diberikan omeprazole sebelum induksi gastritis, kelompok perlakuan 1 (P1) diberikan infusa temu putih 6% sebelum induksi gastritis, dan kelompok perlakan 2 (P2) diberikan infusa temu putih 60% sebelum induksi gastritis. Hasil penelitian menunjukkan bahwa infusa temu putih 60% dan 6% dapat menurunkan pH lambung.

Gastritis can be interpreted as a disease that occurs due to inflammation of the mucosal and submucosal layers of the stomach. The content of white turmeric (Curcuma zedoaria) infusion, including curcumin, flavonoids, essential oils, and polyphenols, has not been widely studied as a gastroprotective agent. This study aims to prove the gastroprotective effect of turmeric (Curcuma zedoaria) infusion on Sprague Dawley rats induced by HCl and ethanol. A total of 16 rats were divided into four treatment groups and fasted for 18 hours beforehand. The negative group (KN) was only given gastritis induction with a mixture of HCl and ethanol, the positive group (KP) was given omeprazole before gastritis induction, treatment group 1 (P1) was given 6% white turmeric infusion before gastritis induction, and treatment group 2 (P2) was given infusion 60% white turmeric before induction of gastritis. The results showed that 60% and 6% white turmeric infusion could lower gastric pH.