Efikasi Pemberian Dadih dan Ketan Hitam Sebagai Alternatif Penurun Kolesterol (Antihiperkolesterolemia) Pada Tikus Model Hiperkolesterolemia

Abstract

Hiperkolesterolemia merupakan faktor resiko penyakit kardiovaskular seperti aterosklerosis. Penelitian ini bertujuan menganalisis kadar total kolesterol, trigliserida, High Density Lipoprotein (HDL), dan Low Density Lipoprotein (LDL) dalam darah, serta kolesterol organ hati pada tikus hiperkolesterolemia yang diberi dadih dan ketan hitam (emping-dadih) dibandingkan dengan obat atorvastatin. Penelitian ini menggunakan 10 ekor tikus putih yang dibagi menjadi dua kelompok perlakuan, yaitu kelompok “emping-dadih” (ED) dan atorvastatin (AT). Penelitian dilaksanakan 9 minggu mencakup 5 minggu pertama diberikan diet kolesterol 1%, dan 4 minggu terakhir kelompok ED diberikan “emping-dadih” serta kelompok AT diberikan atorvastatin. Berdasarkan studi ini dapat disimpulkan bahwa “emping-dadih” dengan dosis tertentu mempunyai kemampuan yang sama dengan atorvastatin dalam menurunkan kadar kolesterol total dan LDL. Keduanya tidak memiliki efek berbeda terhadap kadar HDL. “Emping-dadih” berpotensi menaikkan kadar trigliserida walaupun dalam studi ini masih dalam rentang normal. “Emping-dadih” juga mampu menjaga kadar kolesterol hati tikus sama seperti kelompok yang diberi atorvastatin.

Hypercholesterolemia is a risk factor for cardiovascular diseases such as atherosclerosis. This study aimed to analyze the levels of total cholesterol, triglycerides, High Density Lipoprotein (HDL), and Low Density Lipoprotein (LDL) in the blood, as well as liver cholesterol in hypercholesterolemic rats given dadih and black glutinous rice (emping-dadih) compared to atorvastatin. This study used 10 white rats divided into two treatment groups, i.e., the group treated with “emping-dadih” (ED) and the group treated with atorvastatin (AT). This study was conducted for 9 weeks. The first 5 weeks, all groups were given 1% cholesterol diet, and the last 4 weeks, the ED group was given emping dadih, and AT group was given atorvastatin. Based on this study, “emping dadih” can be concluded that “emping-dadih” with a certain dose has the same ability as atorvastatin in reducing total and LDL cholesterol levels. Both also have no different effect on HDL levels. “Emping dadih” has a potential to raise triglyceride levels even though in this study it is still within the normal range. “Emping-dadih” also maintained liver cholesterol levels the same as the atorvastatin rat group with no noticeable difference.