| dc.contributor.advisor | Gunanti, Gunanti | |
| dc.contributor.advisor | Noviana, Deni | |
| dc.contributor.advisor | Harlina, Eva | |
| dc.contributor.author | Rahmi, Nur | |
| dc.date.accessioned | 2023-05-05T06:26:29Z | |
| dc.date.available | 2023-05-05T06:26:29Z | |
| dc.date.issued | 2023-05 | |
| dc.identifier.uri | http://repository.ipb.ac.id/handle/123456789/117276 | |
| dc.description.abstract | Infark miokardium merupakan suatu kondisi terbentuknya nekrosis
miokardium ditandai dengan penurunan cardiac output yang memicu terjadinya
acute kidney injury. Terapi stem cell adalah metode yang dapat memperbaiki infark
miokardium. Penelitian ini bertujuan untuk mempelajari efektivias terapi stem cell
placenta tunggal maupun kombinasi kardiomiosit pada babi yang mengalami infark
miokardium ditinjau dari nilai ureum, kreatinin dan histopatologi organ ginjal.
Sebanyak 9 ekor babi di bagi menjadi tiga kelompok, yaitu tanpa terapi (K1), terapi
stem cell placenta tunggal (K2), dan terapi kombinasi kokultur kardiomiosit (K3).
Seluruh babi dilakukan ligasi arteri circumflexa coronary untuk mensimulasikan
iskemia jantung dan setelah 1 jam ligasi dilakukan pemberian terapi. Hasil
penelitian menunjukkan penurunan nilai ureum dan kreatinin pada K2 dan K3.
Hasil histopatologi ditemukan kongesti atrofi glomerulus, dan nekrosis tubulus.
Berdasarkan uji analysis of variance (ANOVA) menunjukkan ada perbedaaan yang
nyata (p < 0,05). Disimpulkan bahwa pemberian terapi stem cell placenta maupun
yang dikombinasi dengan kokultur kardiomiosit dapat menurunkan nilai ureum,
kreatinin, dan memperbaiki jaringan ginjal secara histopatologi.
Kata kunci: infark miokardium, ginjal, histopatologi, ureum, kreatinin, stem cell | id |
| dc.description.abstract | ABSTRACT
Myocardial infarction is a condition where myocardial necrosis develops
which is characterized by a decrease in cardiac output that triggers acute kidney
injury. Stem cell therapy is a method that can repair myocardial infarction. This
study aims to study the effectiveness of placental stem cell therapy alone or in
combination with cardiomyocytes in pigs with myocardial infarction in terms of
urea, creatinine and histopathological values of the kidneys. A total of 9 pigs were
divided into three groups, namely without therapy (K1), single placenta stem cell
therapy (K2), and combined therapy with cardiomyocyte coculture (K3). All pigs
underwent coronary circumflex artery ligation to simulate cardiac ischemia and
after 1 hour of ligation, therapy was given. The results showed an decreased in urea
and creatinine values in the K2 and K3 groups. Histopathological results were
congestion, glomerular atrophy, and tubular necrosis. Based on the analysis of
variance (ANOVA) test, it showed that there was a significant difference (p<0.05).
It was concluded that administration of placental stem cell therapy or in
combination with cardiomyocyte coculture can reduce urea, creatinine,and
improve kidney tissue histopathologically.
Keywords: myocardial infarction, kidney, histopathology, urea, creatinine, stem
cell | id |
| dc.language.iso | id | id |
| dc.publisher | IPB University | id |
| dc.title | Efektivitas Terapi Stem Cell pada Infark Miokardium Ditinjau dari Nilai Ureum, Kreatinin dan Histopatologi Ginjal. | id |
| dc.title.alternative | Effectiveness of Stem Cell Therapy in Myocardial Infarction a Review of Values Creatinine, Ureum and Kidney Histopathology | id |
| dc.type | Thesis | id |
| dc.subject.keyword | stem cell | id |
| dc.subject.keyword | kidney | id |
| dc.subject.keyword | myocardial infarction | id |
| dc.subject.keyword | ureum | id |
| dc.subject.keyword | creatinine | id |
