Profil Hematologi Anjing Setelah Pemberian Obat Anti Caplak Sarolaner Dosis Tunggal

Abstract

ABSTRAK NURMASITA. Profil Hematologi Anjing Setelah Pemberian Obat Anti Caplak Sarolaner Dosis Tunggal. Dibimbing oleh ANITA ESFANDIARI DAN SUPRATIKNO.

Sarolaner merupakan obat baru anti caplak golongan isoksazolin yang efektif melawan infestasi caplak pada anjing. Penelitian ini bertujuan untuk mempelajari profil hematologi anjing yang diberi obat anti caplak berbahan aktif sarolaner dosis tunggal. Sebanyak lima ekor anjing bercaplak digunakan dalam penelitian ini. Anjing diberi obat anti caplak berbahan aktif sarolaner dengan dosis tunggal sebesar 2 mg/kg BB secara oral. Sampel darah diambil dari vena cephalica antebrachii sebelum diberikan sarolaner (H0, pre-treatment), pada H+7 (7 hari post-treatment), dan pada H+30 (30 hari post-treatment) untuk dianalisis terhadap parameter hematologi meliputi jumlah eritrosit, kadar hemoglobin, nilai hematokrit, dan indeks eritrosit (nilai MCV dan MCHC). Hasil pengamatan menunjukkan bahwa terdapat perbedaan nyata pada nilai hematokrit pada H+7 dan H+30 (P<0.05), namun tidak ada perbedaan nyata pada jumlah eritrosit, kadar hemoglobin, nilai MCV dan nilai MCHC (P>0.05) pada periode waktu yang sama. Pemberian obat anti caplak berbahan aktif sarolaner dosis tunggal sebesar 2 mg/kgBB pada anjing bercaplak mampu meningkatkan rataan nilai hematokrit pada hari ke-7 dan 30 setelah pemberian.

Kata kunci: anjing, caplak, profil hematologi, sarolaner.

ABSTRACT

NURMASITA. Hematological Profiles of Dogs Received Single Dose of Sarolan- er Anti-Ticks Drug. Supervised by ANITA ESFANDIARI and SUPRATIKNO.

Sarolaner is a new anti-tick from the isoxazoline group, effective against tick infestations in dogs. The objective of this study was to read the hematological profile of dogs that were given a single dose of anti-tick with sarolaner active in- gredient. There are five ticked dogs used in this study. Anti-tick were given to the dogs with sarolaner active ingredient in a single dose of 2 mg/kg body weight via oral. Blood samples were taken from the cephalic antebrachial vein. The samples were taken before being given a sarolaner (H0, pre-treatment), at H+7 (7days post-treatment), and H+30 (30 days post-treatment). The samples were analyzed for hematological parameters, including the number of erythrocytes, hemoglobin level, hematocrit value, and erythrocyte index (MCV and MCHC values). The re- sults showed that there was a significant difference in the hematocrit value at H+7 and H+30 (P<0.05), but there was no significant difference in the number of erythrocytes, the level of haemoglobin, MCV values, and MCHC values (P>0.05) in the same period. The administration of anti-tick with sarolaner active ingredient in a single dose of 2 mg/kg BW in ticked dogs increased the average hematocrit value on the 7th and 30th days after administration.

Keywords: dog, hematological profile, sarolaner, tick.