Ekstrak Jahe (Zingiber officinale Roscoe) Penghambat Oksldasl LDL

Abstract

Oxidative modifcation of DL is believed to play an importad rde in athemgenesis. DthlonnneH,ane exfmt of ginger hhomas exhibited a stmng antioxid& edivrty using lindeic acid as substrafe. We investgated the in vRro effect of these extract enkhment on the prwention of oxidative DL by CuSO* Plasma was supplemented with 43, 430, or 4300 ,ugh/ dichhethane extract in dmethykulMie (DMSO) (10 pl DMSO per ml plasma), incubated, and the UIL was $dated. Lag m e and maloneldehide conteni was anaiized a& the isdded LDL was oxidhed using CuSOc The muif showed that dth/omn?ethane extract of ginger rhizomes supkmentation prdonged lag phase tand reduced mdonddehide Ibrmdhn depended on hk c m . C m r m of 43 iMd 4300 ,ugh/ plasma of these exfract reduced msdonaldehide iunnetihn by 35,29 % and 69,72 % respectively, M not signiikenf in prdonged lag phase. Concentration of these extract with largest prolonged lag phase (82,16 %) mireduced maion&We iimnahn ( 7 4 , % was 430 ,ug!mIplasrna This research has shown that gngw extract is ctqWe of pl?decfhgDL from Oxi'dation.