Isolation, Identification and Tyrosinase Inhibitory Activities of the Extractives from Allamanda cathartica

dc.contributor.author	Yamauchi, Kosei
dc.contributor.author	Mitsunaga, Tohru
dc.contributor.author	Batubara, Irmanida
dc.date.accessioned	2015-10-08T07:16:18Z
dc.date.available	2015-10-08T07:16:18Z
dc.date.issued	2011
dc.identifier.uri	http://repository.ipb.ac.id/handle/123456789/76471
dc.description.abstract	Tyrosinase inhibitory activity of the extractives from A. cathartica was examined and their new bioactivity and potent active compounds were identified. Five compounds, glabridin, new lignan, kaempferol, naringenin, and allamandicin, were isolated by a series of chromatography, and identified by NMR and LC-MS. Among them, glabridin had the high-est tyrosinase inhibitory activity (IC50:2.93 μM) which is 15 times stronger than that of kojic acid used as positive con-trol (IC50:43.7 μM). Moreover the lignan was indentified as 1-[3-(4-allyl-2,6-dimethoxyphenoxy)-4-methoxyphenyl] pro- pane-1,2,diol which was a novel lignan.	en
dc.language.iso	en
dc.publisher	SciRes
dc.relation.ispartofseries	2, 167-172;
dc.subject.ddc	Allamanda c athartica	en
dc.subject.ddc	Tyrosinase	en
dc.subject.ddc	Glabridin	en
dc.subject.ddc	Kaempferol	en
dc.subject.ddc	Naringenin	en
dc.subject.ddc	Allamandicin	en
dc.title	Isolation, Identification and Tyrosinase Inhibitory Activities of the Extractives from Allamanda cathartica	en
dc.type	Article	en