Flavonoid from Intsia palembanica as Skin Whitening Agent

dc.contributor.author	I. Batubara
dc.contributor.author	L.K. Darusman
dc.contributor.author	T. Mitsunaga
dc.contributor.author	H. Aoki
dc.contributor.author	M. Rahminiwati
dc.date.accessioned	2015-10-07T07:02:04Z
dc.date.available	2015-10-07T07:02:04Z
dc.date.issued	2011
dc.identifier.issn	1727-3048
dc.identifier.uri	http://repository.ipb.ac.id/handle/123456789/76459
dc.description.abstract	This study aims to obtain active compounds from Intsia palembanica with skin whitening activity. I. palembanica methanol extracts were separated using chromatography techniques and yielded 3 flavanols. Isolated compounds along with 6 other flavonoid compounds were analyzed for tyrosinase inhibitory activity and inhibition of melanin cell growth in Bl 6 cell. The results showed that (-)-robidanol is the most potent tyrosinase inhibitor (IC50 monophenolase 8.7 μM; diphenolase 26.6 μM) and inhibit melanin synthesis 46.2% compared to control (at 100 μM). In conclusion, (-)-robidanol is the best compound as a whitening agent.	en
dc.language.iso	en
dc.publisher	Asian Network for Scientific Information
dc.relation.ispartofseries	11 (8): 475-480, 2011;
dc.subject.ddc	Instia palembanica	en
dc.subject.ddc	(-)-robidanol	en
dc.subject.ddc	tyrosinase inhibitor	en
dc.subject.ddc	melanin	en
dc.subject.ddc	whitening agent	en
dc.title	Flavonoid from Intsia palembanica as Skin Whitening Agent	en
dc.type	Article	en