Karakteristik dan efektivitas penetrasi kafein terjebak dan tersalut nanopartikel kitosan sebagai antiselulit

Abstract

Chitosan used as drug carrier because of is natural polycationic and easily modified in chemical and physical properties. In this research chitosan was chemically modified by coating and entrapping anti-cellulite active substance of caffeine and physically modified by minimizing chitosan particle size into nanoparticles size. The purpose of this research is to characterize the chitosan nanoparticles from its morphology, particle size, function of group, the value of adsorption efficiency, and effectiveness of chitosan nanoparticles against in vitro penetration of caffeine as anti-cellulite using Franz diffusion cell. The morphology characterization test of caffeine trapped in chitosan nanoparticles and caffeine coated by chitosan nanoparticles resulting a smooth surface, slight convex shape, and agglomerated particles; average size of particles are 232.74 nm and 226.62 nm respectively; the function group showed a shift of wave number of amide III groups (-CN) and hydroxyl groups (-OH); the caffeine adsorption efficiency are 51,35% and 64,63% respectively. The result of effective penetration are 1.089.65 ± 10.7 μg/cm2 and 2.170.03 ± 6.85 μg/cm2 respectively.