Stabilitas mikrokapsul ketoprofen tersalut kitosan-alginat

Abstract

Abstract : Drug preparations for stability test has been done in previous research, with composition of Chitosan 1.75% (w/v), alginate 0.625% (w/v), glutaraldehyde 4.5% (v/v), and ketoprofen 0.8% (w/v), added by Tween 80 of three levels (1, 2, 3 %). All mixtures were shaken under three different times (1, 2, 3 hours). As a new drug preparation, the stability of ketoprofen microcapsule has to be studied. The purpose is to measure the resistance of the coat during storage and use. The stability was tested using accelerated method in climatic chamber under 40±2 °C and relative humidity of 75±5 % in 3 months. The parameter was measured every week included moisture content by using moisture analyzer and ketoprofen content using ultraviolet spectrophotometer at wavelength 254.7 nm. All nine formulas showed that they have high (>10%) and fluctuating moisture content, while ketoprofen content decreased with different reaction kinetics model for each formula. Formula 1 and 2 followed second orders, formula 3, 4, 5, 6, 7, 9 have followed kinetics Avrami-Erofeev model, and formula 8 followed Proud-Tompkins kinetics model. Formula 8 was best formula than the others. It have ketoprofen content percentage still coated after 3 months, degradation rate constant, and shelf life were 91.47%, 0.0875 week-1, and 14.01 week, respectively. The degradation of ketoprofen presumably followed autocatalytic reaction mechanism controlled by formation and growth of reaction core.