dc.contributor.author | Sugita, Purwantiningsih | |
dc.contributor.author | Setyani, Yunia Anggi | |
dc.contributor.author | Wukirsari, Tuti | |
dc.contributor.author | Srijanto, Bambang | |
dc.date.accessioned | 2013-06-04T01:42:26Z | |
dc.date.available | 2013-06-04T01:42:26Z | |
dc.date.issued | 2013-06-04T01:42:26Z | |
dc.identifier.isbn | 978-979-95093-6-9 | |
dc.identifier.uri | http://repository.ipb.ac.id/handle/123456789/63969 | |
dc.description | Prosiding Seminar Nasional Sains III Hal.230-240 | en |
dc.description.abstract | Abstract : High dose ketoprofen administration as anti-inflammatory drug can cause gastrointestinal bleeding. To minimize this drawback, we have successfully double coated guar gum-modified chitosan microcapsules containing ketoprofen with alginate. The results showed that this double coating had improved the microcapsule’s stability in the gastric acid medium. The ketoprofen releasing kinetic models, both at gastric and intestinal pH, are dominated by the Korsmeyer-Peppas model suggesting that this action is following the diffusion mechanism. This kinetic model is the closest approximation to the real releasing condition. | en |
dc.description.sponsorship | Fakultas MIPA – Institut Pertanian Bogor
bekerja sama dengan
MIPAnet | en |
dc.language.iso | en | |
dc.relation.ispartofseries | 30 Desember 2010; | |
dc.subject | chitosan | en |
dc.subject | ketoprofen | en |
dc.subject | microcapsule | en |
dc.subject | dissolution | en |
dc.title | Dissolution behavior of ketoprofen double coted by chitosan-gum guar with alginat-CaCl2 | en |