Sintesis dan uji sitotoksik in vitro senyawa 2-Hidroksinikotinil oktilamida terhadap sel kanker leukimia murin p388

Abstract

The novel compounds of2-hydroxynicotinyl octylamide (NOA) were synthesized by modifying of the UK-3A compound known biologically active to inhibit bacterial and cancer cell growth. Synthesis of2-hydroxynicotinyl octylamide (NOA) were carried out in one step reaction for the second compound. NOA was synthesized by amidation reaction between 2-hydroxynicotinic acid and octylamin yielded 76.1% ofthe product. The compound were confirmed with Fourier transformed infrared spectrophotometry, liquid chromatography mass spectroscopy, and nuclear magnetic resonance spectrometry. In vitro test on breast cancer T47D demonstrated that the inhibition the growth ofcancer cells with IC50 for NOA were 32.0 )Jg/mL. The IC 50 values indicated that the synthesis products were sufficiently potential to be anticancer for murine leukemia P388 cells.