Variasi Alel dari Gen 5-HTT (Penyandi Agresivitas) pada Macaca nemestrina
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Date
2010Author
Erniasari, Ikka
Perwitasari, Rd. Roro Dyah
Farajallah, Achmad
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Macaca nemestrina is an aggressive primate. The aggresivity is influenced by many factors, one of them is by a gene. The 5-HTT gene encodes the serotonin transporter that affects the regulation of serotonergic system and its receptor by modulating the concentration of serotonin in extracellular fluid. Variation in promoter and intron region can change the transcriptional activity of the 5-HTT gene, mainly the activity of the transporter and serotonin uptake. The transporter change activity influenced aggressivity, emotion, motor function, and some cognitive traits in primates. This research aimed to determine alelles variant of 5-HTT gene (encoding aggresivity) in M. nemestrina. Samples used in this research consisted of 56 M. nemestrina. The gene was amplified by the Polymerase Chain Reaction (PCR) method. Amplification in promoter region revealed two alleles and three genotypes with the frequencies of L and S alleles were 88,18% and 11,82%, respectively. Amplification of the third intron region showed two alleles with the frequency of l and s alleles were 55,4% and 44,6%, respectively. None of the individual had s/s genotype in the third intron region. Short allele was dominant to long allele. The presence of at least one short allele decreased transcription activity. There was one individual with S/S genotype in promoter region that was possibly to be the alpha male in the group.
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