The influence of Sauropus androgynus (L.) Merr. leaves and papaverine on the glucose absorption and glucose metabolism in the liver

Abstract

This experiment was to investigate the influence of the Saurqous sndrogynus {SA) leaves and the role of its papaverine (PPV) content on the glucose absorption and glucose metabolism in the liver. Thirty six male White New Zealand Rabbits divided into three groups of 12 animals each. Three solutions were administrated orally twice a day to each gmup svcR as, distilled water to the control group, PPV-hydrochloride solution 0.5 % (2 mg PPVlkg body weight) to the PPV group, and a suspension of ground SA leaves 14.17 % (PPV dose equivalent to 2 mgkg body weight) to the SA group. After 5 days of application, blood samples at hepatic and portal vein were taken from 4 rabbits of each group by surgery procedure. This procedure was repeated after 70 and 15 days of application. Glucose concentration of serum samples was determined using test fit. The glucose absorption obviously increased after 15 days of PPV and SA leaves application, it could be seen that glucose concentration in the portal vein enhanced significantly at this time. The administration of SA leaves caused a surplus of glucose in the liver. It was obtained earlier and to a higher extent than after PPV administration. The PPV content of the SA leaves might be plays an important role in the effects of SA leaves.