Pengaruh perlindungan ekstrak rimpang Bangle (Zingiber cassumunar ROXB) terhadap kerusakan hati tikus yang diinduksi CCL4

Abstract

Zingiber cassumunar Roxb known as Bangle, has antioxidative and antiinflammatoty activities. It has been used for medicinal purposes traditionally. The aim of this study was to investigate whether administration of Z. cassumunar exiracts orally may prevent acute liver damage induced by carbontetrachloride (CCk) in rats. The study was canied out on 5 groups of male Spmgue-Dawley rats (n=5). Group 1 was given ethyl acetate fraction of Bangle rhizome extract (30 rngncg bwJ (KS), group 2 was given dry juice of6angle hizonm (30 mghg bw) (SK), group 3 was given curcuminoid (30 mghg bw) (KURJ, group 4 as negative control (KN) given 5% T w w 80 solufion (10 mhg bw) and Group 5 as control (K). Carbontetrachloride 0,l mkg bw was given orally after 7 days to group KS, SK, KUR and KN. Rats were tminated 24 hours aiter CClr-lnduction. Liver injury was evaluated by analyzed SGPT and SGOT aclivities from the senim and histopathologycal examination was conducted on the liver. The results clearly indicated that extracts of Z. cassumunar cwM r e d u d significantly the degree of liver damage induced by Ca4. It may be concluded that Z. cassumunar rhizome could be used as substance for hepatoprotector.