The Effect of Mamordica charalltia L. Powder on The Status of Antioxidant Superoxide Dismutase in Liver and Kidney of Diabetic Rats
Date
2010Author
Wresdiyati, Tutik
Astawan, Made
Zulfanedi, Yoli
Sinulingga, Teguh Suranta
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The status ojcnlioxidal;f superoxide dismurase (SOD) \las repfJrted decrecsed m the Jj,'er tissues f.;/diaberlcexperimenral Macaea fascicularis. The aim oflhe study was to observe the effect of pare (Mam:>rdica charantia) olllhe status o/SOD in the liver and kidney of diabetic experimental rats. The SOD was localized using immunohistochemical technique. A lotal 0/20 male Wistar rats were usedJor this study. They were divided into Jour groups: (I) negative control group, (2) positi~'e control group (diabetes mellitus groupIDM); (3) and (4) groups were DM groups that treared wilh 5 and 10% pare powder. The DM condition was achieved by alloxan (J 10 mglKgBB) induction. Treatment a/pare was done/or 28 days. The results showed that pare increased the status oj antioxidant SOD in the liver and kidney oj diabetic experimental rats. The 10% pare powder gave better results than that 015%. Tlfe results suggested thai pare powdu can be used to increase the status 0/ antioxidant ;n fhe OXidative stress condition, such as diabetes mellitus. Keywords: superoxide dismutase, Jlamordica charanlta, diabetes mellitus, liver, kidney, immunohistochemistry