| dc.description.abstract | Vesicular Acetylcholine Transporter (VAChT) is a kind of membrane protein that is
usually found in SVs of cholinergic nerve system1. VAChT is 500-amino acid polypeptides
consisting of 12 trans-membrane helices (TMs) (Figure 1), with an N-C terminal in the
cytosol, and a large N-glycosylated loop between the first and second TMs. It is similar to
VMATs (VMAT1 and VMAT2). These two have 60% amino acid similarity and they are 40%
identical to VAChT (Figure 2). VAChT protein is coded by the SLC18A3 segment and this
segment is expressed by the SLC18 family. SLC18 itself is a member of MFS. VAChT is
the part of the drug H+ antiporter-1 family (DHA1, TCID 2.A.1.2)2–4.
As for how of its name, VAChT performs the function as an active transporter
(Figure 3) for the acetylcholine into the SVs1,4. VAChT expressions also regulate the
amount of ACh in the SVs5. It means that the decreased VAChT expression will directly
reduce the level of ACh in SVs. VAChT exchanges two protons per substrate molecule
with very similar initial velocity kinetics and pH dependencies1. It relates to the activity of
VAChT that is able to change tonicity and morphological in SVs6... | id |
