Evaluasi Toksisitas Akut Ginkgo biloba pada Mencit (Mus musculus)

Abstract

Ginkgo biloba is frequently consumed due to its perceived ability to treat a wide range of illnesses and conditions. Acute toxicity testing was conducted to evaluate the safety profile of Ginkgo biloba. The study involved 20 female mice divided into four groups: one control group receiving distilled water and three treatment groupsreceiving Ginkgo biloba at doses of 5, 10, and 15 g/kg body weight, respectively. The administration of Ginkgo biloba and distilled water was performed via gastric tube in a single dose, with observations commencing 14 days post- treatment. The evaluation of observation are mortality, physiological responses, and clinical symptoms. Additional parameters examined included body weight, absolute organ weight, relative organ weight. The results of the acute toxicity test on Ginkgo biloba revealed no significant differences in clinical symptoms, body weight, organ weight, or no mortality rates. It was concluded that Ginkgo biloba is practically harmless substance.