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      Antidiarrheal Activity of Bajakah Tampala Wood (Spatholobus littoralis Hassk.) Decoction in Mice (Mus musculus)

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      Date
      2024
      Author
      Azzhara, Cellin Rubianti
      Pisestyani, Herwin
      Sutardi, Lina Noviyanti
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      Abstract
      Secara empiris, kayu bajakah tampala telah digunakan oleh masyarakat Dayak secara turun-temurun sebagai pengobatan untuk berbagai macam penyakit. Penelitian ini bertujuan mengetahui kandungan senyawa kayu bajakah tampala dengan menggunakan skrining fitokimia, rebusan kayu bajakah tampala memiliki khasiat sebagai antidiare dan konsentrasi paling efektif yang memberikan efek antidiare terbaik pada mencit. Pengujian Kelompok eksperimen terdiri dari 2 kelompok kontrol (positif dan negatif) dan 3 kelompok perlakuan dengan konsentrasi rebusan kayu bajakah tampala (25%, 50%, 100%). Mencit diinduksi secara oral dengan rebusan kayu bajakah tampala sebelum pemberian minyak jarak. Hasil tes fitokimia kayu bajakah tampala mengandung senyawa metabolit sekunder yaitu alkaloid, flavonoid, saponin, dan tannin. Hasil penelitian ini menunjukkan bahwa konsentrasi terbaik menunjukan pada konsentrasi 25% dan kayu bajakah tampala mampu memberikan perlindungan terhadap diare yang disebabkan oleh minyak jarak.
       
      Empirically, bajakah tampala wood has been used by Dayak people for generations as a treatment for various diseases. This study aims to find out the content of bajakah tampala wood compounds using phytochemical screening, to determines bajakah tampala wood decoction has efficacy as an anti-diarrhea and the most effective concentration that provides the best antidiarrheal effect in mice. The experimental groups consisted of two control groups (positive and negative) and three treatment groups with bajakah tampala wood decoction concentrations (25%, 50%, 100%). Following treatment, observations were conducted on the test parameters, including diarrhea frequency, stool consistency, onset of diarrhea, duration of diarrhea, and recovery time. Animals were orally treated with bajakah tampala wood decoction before administering castor oil. The results of phytochemical screenings of bajakah tampala wood contain secondary metabolite compounds, namely alkaloids, flavonoids, saponins, and tanninss. The results of this research show that the best concentration is 25% and bajakah tampala wood can provide protection against diarrhea caused by castor oil.
       
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      http://repository.ipb.ac.id/handle/123456789/153369
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      • UT - Veterinary Clinic Reproduction and Pathology [2167]

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      Copyright © 2020 Library of IPB University
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